Dendritic cells (DCs) are the sentinels of the immune system, sensing a diverse array of pathogens to stimulate a robust and appropriate immune response. To initiate responses to highly disparate challenges, DCs have diversified into multiple phenotypically, anatomically, and functionally distinct cell types. As a result of the application of new single-cell technologies, the full extent of this diversity, as well as the developmental relationships of the DC lineages, is currently undergoing reassessment. Here, we review the cellular and molecular evidence that underpins current models of DC differentiation and functional diversification in the murine and human systems. We discuss these models in the context of the diversity revealed by single-cell studies and propose that understanding DC identity will require defining the regulatory interactions that control gene expression in these cells.
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Schraml BU, Reis e Sousa C. Schraml BU, et al. Curr Opin Immunol. 2015 Feb;32:13-20. doi: 10.1016/j.coi.2014.11.001. Epub 2014 Dec 3. Curr Opin Immunol. 2015. PMID: 25553392 Review.
Belz GT, Nutt SL. Belz GT, et al. Nat Rev Immunol. 2012 Jan 25;12(2):101-13. doi: 10.1038/nri3149. Nat Rev Immunol. 2012. PMID: 22273772 Review.
Paul F, Amit I. Paul F, et al. Curr Opin Immunol. 2014 Oct;30:1-8. doi: 10.1016/j.coi.2014.04.004. Epub 2014 May 13. Curr Opin Immunol. 2014. PMID: 24820527 Review.
Murphy KM. Murphy KM. Adv Immunol. 2013;120:239-67. doi: 10.1016/B978-0-12-417028-5.00009-0. Adv Immunol. 2013. PMID: 24070387 Review.
Amon L, Lehmann CHK, Baranska A, Schoen J, Heger L, Dudziak D. Amon L, et al. Int Rev Cell Mol Biol. 2019;349:55-151. doi: 10.1016/bs.ircmb.2019.10.001. Epub 2019 Nov 15. Int Rev Cell Mol Biol. 2019. PMID: 31759434 Review.
Yoon JH, Bae E, Nagafuchi Y, Sudo K, Han JS, Park SH, Nakae S, Yamashita T, Ju JH, Matsumoto I, Sumida T, Miyazawa K, Kato M, Kuroda M, Lee IK, Fujio K, Mamura M. Yoon JH, et al. Life Sci Alliance. 2024 Jul 3;7(9):e201900581. doi: 10.26508/lsa.201900581. Print 2024 Sep. Life Sci Alliance. 2024. PMID: 38960622 Free PMC article.
Shen X, Li X, Wu T, Guo T, Lv J, He Z, Luo M, Zhu X, Tian Y, Lai W, Dong C, Hu X, Wu L. Shen X, et al. Cell Mol Immunol. 2024 Jul;21(7):752-769. doi: 10.1038/s41423-024-01179-1. Epub 2024 May 31. Cell Mol Immunol. 2024. PMID: 38822080 Free PMC article.
De Leeuw E, Hammad H. De Leeuw E, et al. Eur Respir Rev. 2024 May 29;33(172):230250. doi: 10.1183/16000617.0250-2023. Print 2024 Apr 30. Eur Respir Rev. 2024. PMID: 38811032 Free PMC article. Review.
Wang H, Li Y, Yu Q, Wang M, Ainiwaer A, Tang N, Zheng X, Duolikun A, Deng B, Li J, Shen Y, Zhang C. Wang H, et al. Trop Med Infect Dis. 2024 Apr 25;9(5):95. doi: 10.3390/tropicalmed9050095. Trop Med Infect Dis. 2024. PMID: 38787028 Free PMC article.
Chen KY, Sun WL, Wu SM, Feng PH, Lin CF, Chen TT, Lu YH, Ho SC, Chen YH, Lee KY. Chen KY, et al. Cells. 2024 May 20;13(10):878. doi: 10.3390/cells13100878. Cells. 2024. PMID: 38786101 Free PMC article.